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 CoQ10

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PostSubject: Coenzyme Q10 dosage   December 25th 2014, 5:56 pm

Dosing



The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.


Adults (18 years and older)



In general, manufacturers have recommended doses of CoQ10 ranging between 22-400 milligrams.


To treat Alzheimer's disease, 90-360 milligrams of idebenone (a man-made compound similar to CoQ10) has been taken by mouth daily in single or divided doses for 6-16 months. A dose of 400 milligrams of CoQ10 has been taken by mouth three times daily for 16 weeks.


To treat amyotrophic lateral sclerosis (ALS), 1,800 or 2,700 milligrams of CoQ10 has been taken by mouth daily in three divided doses for nine months. Doses of CoQ10 as high as 3,000 milligrams have been taken by mouth daily for eight months.


To treat chest pain, 60-600 milligrams of CoQ10 has been taken by mouth daily in single or divided doses for four weeks.
As an antioxidant, 60-150 milligrams of CoQ10 has been taken by mouth daily for 2-12 weeks. A dose of 30 milligrams of CoQ10 in oil or 20 milligrams of CoQ10 as a powder has been taken by mouth three times daily for two months. A dose of 100 milligrams of CoQ10 has been taken by mouth daily before hemodialysis over a six-month period.


To treat muscle control problems, 5-30 milligrams per kilogram of CoQ10 has been taken by mouth daily for 2-5 years. Doses of 300-3,000 milligrams of CoQ10 have been taken by mouth daily. A dose of 5 milligrams per kilogram of idebenone has been taken by mouth daily for up to five years.


To treat weakening of the heart muscle, 30-600 milligrams of CoQ10 has been taken by mouth daily for up to eight years. A dose of 2 milligrams per kilogram of CoQ10 has been taken by mouth in two or three divided doses along with regular heart medication, and increased to a maximum of 10 milligrams per kilogram by mouth daily for six months. A dose of 0.6 milligrams per kilogram has been taken by mouth daily for nine months.


To prevent heart disease, 200 milligrams of CoQ10 has been taken by mouth once daily for 12 weeks.


To treat side effects of chemotherapy, 50-90 milligrams of CoQ10 have been taken by mouth daily. An ointment containing ubiquinone has been applied to the skin. CoQ10 has been injected into the vein at a dose of 1 milligram per kilogram the day before anticancer treatment, on the day of treatment, and for two more days after treatment.


To treat coronary heart disease, 20-100 milligrams of CoQ10 have been taken by mouth three times daily for 4-8 weeks.


To treat type 1 diabetes, 100 milligrams of CoQ10 has been taken by mouth daily for 12 weeks.


To treat type 2 diabetes, 100 milligrams of CoQ10 has been taken by mouth twice daily for up to 12 weeks.


To improve exercise performance, doses of 50-300 milligrams of CoQ10 have been taken by mouth daily for up to 12 weeks. A dose of 100 milligrams or 300 milligrams of CoQ10 has been taken by mouth in two divided doses daily for one week, with one dose of three capsules on the morning of the eighth day prior to exercise.


To treat fibromyalgia, 300 milligrams of CoQ10 have been taken by mouth daily for nine months.


To improve blood vessel widening, 200 milligrams of CoQ10 have been taken by mouth daily for 12 weeks.


To treat gum disease, 5 milliliters of CoQ10 (200 milligrams per milliliter) in corn oil have been taken by mouth daily in divided doses.CoQ10 has been taken by mouth in soybean oil at a concentration of 85 milligrams per milliliter once per week for six weeks.


To treat hearing loss, 160-200 milligrams of Q-TER® have been taken by mouth once daily for 7-30 days. CoQ10 has been used as an 85 milligram per milliliter suspension in soybean oil and applied directly to the gum.


To treat heart attack, 120 milligrams of CoQ10 have been taken by mouth daily for a range of 28 days to one year. A dose of 250 milligrams of liquid CoQ10, followed by 150 milligrams of liquid CoQ10, have been given three times daily for five days through nasal tubes.


To treat chronic myocardial disease, 33 milligrams of CoQ10 has been taken by mouth three times daily for 12 weeks.


To treat heart failure, a dose of 2 milligrams per kilogram of CoQ10 has been taken by mouth daily for one year. Doses of 50-600 milligrams of CoQ10 have been taken by mouth daily for one month to 2 years.


To protect the heart during surgery, a dose of 100 milligrams of CoQ10 has been taken by mouth daily for 14 days before and 30 days after surgery. Doses of 30-200 milligrams of CoQ10 have been taken by mouth daily for 5-7 days before bypass surgery. A dose of 300 milligrams of CoQ10 have been taken by mouth daily for two weeks after surgery. A dose of 600 milligrams of CoQ10 has been taken by mouth in two divided doses at 6 p.m. the evening before the procedure and 6 a.m. the morning of the procedure. A dose of 150 milligrams of CoQ10 (in people weighing fewer than 60 kilograms) or 180 milligrams of CoQ10 (in people weighing more than 60 kilograms) has been taken by mouth in three divided doses daily for 7-10 days before surgery. A dose of 5 milligrams per kilogram of CoQ10 has been injected into the vein two hours before bypass surgery.


To treat hepatitis C, 40 milligrams or 80 milligrams of mitoquinone has been taken by mouth once daily with a glass of water following an overnight fasting period and a minimum of one hour before eating, for 28 days.


To treat HIV/AIDS, 200 milligrams of CoQ10 has been taken by mouth daily as a single dose or in three divided doses.


To treat Huntington's disease, 300-600 milligrams of CoQ10 has been taken by mouth daily for 120 weeks. A dose of 270 milligrams of idebenone (90 milligrams three times daily) has been taken by mouth daily for 52 weeks.


To treat high blood pressure, 60-360 milligrams of CoQ10 has been taken by mouth daily, with the average daily dose being 225 milligrams, for 8-12 weeks.


To treat heart disorders (left ventricular diastolic function), a dose of 20 milligrams of atorvastatin (Lipitor®) have been taken by mouth daily for 3-6 months and supplemented with 300 milligrams of CoQ10 daily (100 milligrams, three times daily) for an additional three months.


To lower cholesterol, 50-100 milligrams of CoQ10 has been taken by mouth daily for up to three months.


To treat male infertility, 30-300 milligrams of CoQ10 has been taken by mouth once daily or in divided doses for up to 26 weeks. Q-absorb® soft gels containing 100 milligrams of CoQ10 have been taken by mouth as one soft gel twice daily for six months.


To treat migraine, 150-300 milligrams of CoQ10 has been taken by mouth daily for up to three months. Doses of 1-3 milligrams per kilogram of CoQ10 have been taken by mouth in liquid gel capsules daily.


To treat mitochondrial diseases, 120-1,200 milligrams of CoQ10 has been taken by mouth daily for up to one year. A liquid form of CoQ10 has been taken by mouth at a dose of 5 milligrams per kilogram daily. A dose of 2 milligrams per kilogram of CoQ10 has been taken by mouth daily for six months.


To treat muscular dystrophies, 100 milligrams of CoQ10 has been taken by mouth daily.


To treat muscle disease caused by statins, 100-240 milligrams of CoQ10 (including Q-Sorb™) has been taken by mouth daily for up to 2.5 years.


To treat nerve pain of diabetes, 400 milligrams of CoQ10 has been taken by mouth daily for 12 weeks.


To treat Parkinson's disease, nanoparticular and standard CoQ10 formulas have been taken by mouth in doses of 300-2,400 milligrams daily for four weeks to 16 months.


To treat Peyronie's disease (pain and curvature of penis), 300 milligrams of CoQ10 have been taken by mouth daily for a period of 24 weeks.


To treat high blood pressure of pregnancy, 100 milligrams of CoQ10 has been taken by mouth twice daily (Q-absorb®) until delivery, a total of about 20-24 weeks.


To treat kidney failure, 180-200 milligrams of CoQ10 have been taken by mouth daily for up to eight weeks.


To promote weight loss, 100 milligrams of CoQ10 has been taken by mouth daily for three months.


For anti-aging purposes, a 1 percent CoQ10 cream has been applied to the skin for five months.


Children (under 18 years old)



To treat muscle control problems, 5-20 milligrams per kilogram of CoQ10 has been taken by mouth daily for 3-5 years. A dose of 900-2,250 milligrams daily of idebenone has been taken by mouth for subjects weighing at least 45 kilograms, or 450-1,350 milligrams daily for those weighing 45 kilograms or less for up to one year. Idebenone has been taken by mouth three times daily for a target dose of 5, 15, or 45 milligrams per kilogram daily for six months.


To treat heart muscle weakening, 2 milligrams per kilogram of CoQ10 has been taken by mouth daily in two or three divided doses, increasing to a maximum of 10 milligrams per kilogram daily for six months. A dose of 10 milligrams per kilogram of CoQ10 has been taken by mouth daily in two or three divided doses for eight months.


To treat chemotherapy side effects, 100 milligrams of CoQ10 have been taken by mouth twice daily.


To treat Down's syndrome, 10 milligrams per kilogram of CoQ10 have been taken by mouth daily in single or divided doses for two months, after a low dose of CoQ10 (1 milligram per kilogram daily) for one month.


To treat migraine, 100 milligrams of CoQ10 chewable tablets have been taken by mouth daily for 16 weeks. Doses of 1-3 milligrams per kilogram of CoQ10 have been taken by mouth daily in liquid gel capsules.


To treat mitral valve prolapse, in which a heart valve does not close properly, 0.6-3.4 milligrams per kilogram of CoQ10 have been taken by mouth daily for up to 43 months.


To treat muscular dystrophies, 100 milligrams of CoQ10 has been taken by mouth daily. A dose of 150 milligrams of idebenone has been taken by mouth three times daily (with meals) for 52 weeks.


To treat Prader-Labhart-Willi syndrome, a genetic disorder causing growth and development problems, 2.5 milligrams per kilogram of CoQ10 has been taken by mouth.



Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.


Allergies



Avoid if allergic or sensitive to CoQ10, idebenone, or related substances.


Side Effects and Warnings



CoQ10 is likely safe when up to 3,000 milligrams is taken by mouth daily for up to eight months in healthy people. Nanoparticular CoQ10 is safe at doses of 300 milligrams daily for up to three months. CoQ10 is safe when taken by mouth daily in recommended doses in people who are about to have heart surgery, or those who have heart disease, gum disease, muscle wasting/weakness, Parkinson's disease, Alzheimer's disease, cancer, diabetes, or HIV/AIDS. CoQ10 is also likely safe in healthy people when taken for exercise performance and in children who have chemotherapy side effects. Idebenone is likely safe in doses of up to 60 milligrams per kilogram daily.


Use cautiously in high doses over a long period of time.
Use cautiously in high doses in people with liver problems. Doses of greater than 300 milligrams daily may affect levels of liver enzymes.
Use cautiously in people who have bile duct blockage or liver dysfunction. These conditions may increase CoQ10 levels.
Use cautiously in people who are taking warfarin. CoQ10 may reduce the effectiveness of warfarin.


CoQ10 may increase the risk of bleeding. Caution is advised in people with bleeding disorders or taking drugs that may increase the risk of bleeding. Dosing adjustments may be necessary.


Use cautiously in people who have skin disorders. CoQ10 may cause skin itching and rashes.


Use cautiously in people who have stomach disorders. CoQ10 may cause nausea, upset stomach, and vomiting.


Use cautiously in people who have mitochondrial disorders. CoQ10 may worsen mobility.


Use cautiously in people who have headache or migraines. CoQ10 may cause headache.


CoQ10 may affect blood sugar levels. Caution is advised in people with diabetes or low blood sugar, and in those taking drugs, herbs, or supplements that affect blood sugar. Blood sugar levels may need to be monitored by a qualified healthcare professional, including a pharmacist, and medication adjustments may be necessary.


CoQ10 may cause low blood pressure. Caution is advised in people taking drugs or herbs and supplements that affect blood pressure.


Use cautiously in people who have thyroid problems or those taking thyroid agents. CoQ10 may affect thyroid hormone levels and interact with thyroid agents (such as Synthroid®).


Use cautiously in people who take heart rate-regulating agents. CoQ10 may affect heart rate.


CoQ10 may also cause abnormal breathing, back pain, bronchitis, changes in attention, changes in sperm motility, cholesterol, chest pain, constipation, coughing, diarrhea, dizziness, fainting, falling, fatigue, flu-like symptoms, fungal skin infection, gas, head pressure, hearing loss, heart attack, heartburn, heart dysfunction, indigestion, insomnia, irritability, light sensitivity, loss of appetite, low energy, lung inflammation, muscle pain, night sweats, reduced g-force tolerance, respiratory tract infection, runny nose, sinus inflammation, sore throat, stomach pain, trembling, urinary infection, and viral infection.


Pregnancy and Breastfeeding



There is a lack of scientific evidence on the use of CoQ10 during pregnancy or breastfeeding.
According to the National Institute of Health's Lactation and Toxicology Database (LactMed), CoQ10 is a normal part of human breast milk. Levels may depend on dietary or other differences.
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PostSubject: CoQ10   March 21st 2012, 8:55 pm



Last edited by Admin on December 25th 2014, 6:02 pm; edited 1 time in total
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